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Cardiomyopathy II: Dilated Cardiomyopathy01:30

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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Hyperthyroidism I: Introduction01:25

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Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
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Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
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A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
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[Reversible dilated cardiomyopathy related to hyperthyroidism].

Luiz Eduardo A Wildemberg1, Luciana Lopes de Sousa, Lara P Monteiro da Fonseca

  • 1Serviço de Endocrinologia, Instituto Estadual de Diabetes e Endocrinologia Luis Capriglione, Rio de Janeiro, RJ. lwildemberg@hotmail.com

Arquivos Brasileiros De Endocrinologia E Metabologia
|January 23, 2008
PubMed
Summary

Treatment for hyperthyroidism can reverse severe heart failure, even with reduced ejection fraction. This case study highlights the potential for full recovery after addressing the underlying thyroid condition.

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Area of Science:

  • Cardiology
  • Endocrinology
  • Internal Medicine

Background:

  • Hyperthyroidism is a known cause of heart failure, often high-output.
  • Dilated cardiomyopathy with reduced ejection fraction can also occur in hyperthyroidism.

Observation:

  • A 35-year-old man presented with hyperthyroidism, atrial fibrillation, and severe heart failure (ejection fraction 43%).

Findings:

  • Following radioiodine treatment for hyperthyroidism, the patient experienced complete heart failure reversal.
  • Echocardiographic normalization was achieved, with ejection fraction returning to 69%.

Implications:

  • Thyroid-related heart failure, even severe systolic dysfunction, is potentially reversible with hyperthyroidism treatment.
  • This underscores the importance of screening for thyroid dysfunction in heart failure patients.