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Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Drug Administration and Therapy Phases: Overview01:26

Drug Administration and Therapy Phases: Overview

Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...

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Related Experiment Video

Updated: Jul 8, 2026

Preclinical Positron Emission Tomography with Body Conforming Animal Molds for Cloud-Based Automated Image Analysis in Mice
07:45

Preclinical Positron Emission Tomography with Body Conforming Animal Molds for Cloud-Based Automated Image Analysis in Mice

Published on: October 25, 2024

[New clinical technologies in drug development].

A Otte1, C Rosé, A Zähringer

  • 1Zentrum Klinische Studien, Universitätsklinikum Freiburg, Elsässer Strasse 2, 79110 Freiburg. andreas.otte@uniklinik-freiburg.de

Der Internist
|January 23, 2008
PubMed
Summary

Clinical technologies implementation (CTI) using functional imaging and nuclear medicine accelerates drug development. These techniques reduce risks, optimize drug design, and aid in therapy monitoring for hematologic-oncologic diseases.

More Related Videos

Development of New Therapeutic Applications Using Microfluidics
08:56

Development of New Therapeutic Applications Using Microfluidics

Published on: October 1, 2007

Related Experiment Videos

Last Updated: Jul 8, 2026

Preclinical Positron Emission Tomography with Body Conforming Animal Molds for Cloud-Based Automated Image Analysis in Mice
07:45

Preclinical Positron Emission Tomography with Body Conforming Animal Molds for Cloud-Based Automated Image Analysis in Mice

Published on: October 25, 2024

Development of New Therapeutic Applications Using Microfluidics
08:56

Development of New Therapeutic Applications Using Microfluidics

Published on: October 1, 2007

Area of Science:

  • Nuclear Medicine
  • Pharmacology
  • Drug Development

Context:

  • Functional imaging and therapeutic nuclear medicine technologies represent a novel approach in pharmaceutical research.
  • Clinical technologies implementation (CTI) has significantly impacted drug development strategies over the last 15 years.
  • Early integration of drug metabolism studies during drug design optimization has proven more effective than late-stage characterization.

Purpose:

  • To highlight the role of CTI in reducing risks and costs in drug development decision-making.
  • To demonstrate the utility of CTI in determining go/no-go decisions and optimizing drug dosage.
  • To explore the application of CTI in later clinical phases (3b/4) for therapy monitoring and in developing novel nuclear medicine therapies.

Summary:

  • CTI, integrating functional imaging and therapeutic nuclear medicine, is increasingly vital in early drug development.
  • This approach enhances decision-making by enabling earlier assessment of drug metabolism and guiding optimization.
  • CTI also serves as a valuable tool for therapy monitoring in later clinical trials and for developing targeted therapies like monoclonal antibodies and peptides for hematologic-oncologic conditions.

Impact:

  • Reduced risk and cost in drug development through earlier insights.
  • Improved efficiency in drug design and dosage determination.
  • Potential for novel therapeutic strategies in nuclear medicine, particularly for hematologic-oncologic diseases.