Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiothyreosis.

D Popovici1, J Hertoghe

  • 1C. I. Parhon Institute of Endocrinology, Bucharest, Romania.

Endocrinologie
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Cardiothyreosis, or thyrotoxic heart disease, involves hyperkinetic syndrome and ultrastructural damage due to excess thyroid hormone. Treatment focuses on the underlying cause, with beta-blockers and radioactive iodine being key interventions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biliary cystadenocarcinoma with two types of tumour cells.

Virchows Archiv : an international journal of pathology·2001
Same author

[Remodelling of the crown for occlusal equilibration in partially edentulous patients].

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi·2000
Same author

Esophageal tumor with an unusual histological appearance: a case report.

Hepato-gastroenterology·1998
Same author

The influence of "selenium organicum" upon the hepatic function of carbon tetrachloride poisoned rats.

Romanian journal of internal medicine = Revue roumaine de medecine interne·1995
Same author

The antioxidative action of fibrinogen and the implications of this effect on platelet aggregation.

Romanian journal of internal medicine = Revue roumaine de medecine interne·1994
Same author

Estimation of oxidative stress in cardiovascular diseases.

Romanian journal of internal medicine = Revue roumaine de medecine interne·1994
Same journal

[Bioethics in Romania. Science is a challenge, bioethics is a response].

Endocrinologie·1991
Same journal

Changes in the iodine content of vegetables following the Chernobyl accident.

Endocrinologie·1991
Same journal

Epidemiological surveillance of iodine deficiency in Romania by urinary iodine determinations in children aged 6-16 years from 30 counties.

Endocrinologie·1991
Same journal

Cardiac disturbances in thyrotoxicosis: diagnosis, incidence, clinical features and management.

Endocrinologie·1991
Same journal

Melatonin involvement in oxidative processes.

Endocrinologie·1991
Same journal

Influence of sex and glucocorticoid hormones on 3H cholesterol uptake in the aortic wall and 3H adrenaline in the brain.

Endocrinologie·1991
See all related articles

Area of Science:

  • Cardiology
  • Endocrinology
  • Pathophysiology

Background:

  • Thyrotoxicosis significantly impacts cardiovascular function, leading to a hyperkinetic syndrome.
  • The earliest sign is increased beta-receptors, supported by energy synthesis, but excessive adrenergic action impairs cardiac performance.
  • Ultrastructural damage, including mitochondrial dysfunction and myofibril lysis, occurs despite reduced coronary atherosclerosis.

Purpose of the Study:

  • To discuss the physiopathology, clinical manifestations, and therapeutic strategies for cardiothyreosis.
  • To elucidate the mechanisms behind thyrotoxicosis-induced cardiac dysfunction.
  • To outline current treatment approaches for managing the cardiac effects of hyperthyroidism.

Main Methods:

  • Review of physiopathology, clinical presentation, and therapy of cardiothyreosis.

Related Experiment Videos

  • Analysis of beta-receptor activity, ATP/creatine phosphate synthesis, and mitochondrial function.
  • Examination of clinical data on incidence, age-related severity, and specific cardiac pathologies like arrhythmias and mitral valve prolapse.

    • Main Results:

    • Cardiothyreosis incidence increases with age and pre-existing cardiovascular disease, affecting 25% of patients over 27.
    • Tachyarrhythmias are a major concern, leading to heart failure, thromboembolism, and ventricular fibrillation.
    • Thyrotoxicosis can cause papillary muscle dysfunction and mitral valve prolapse, which are reversible in children.

    Conclusions:

    • Effective treatment of cardiothyreosis requires addressing the underlying etiology, preferably with medical therapy followed by surgery or radioactive iodine.
    • Propranolol is crucial for managing catecholamine excess, with adjusted dosages for the elderly.
    • Verapamil and anticoagulants are valuable adjuncts for specific arrhythmias and embolic risk reduction, particularly in elderly patients.