Is chronic diabetic foot ulcer an indicator of cardiac disease?

M Löndahl1, P Katzman, O Fredholm

  • 1Department of Endocrinology, Lund University Hospital, Sweden. magnus.londahl@skane.se

Journal of Wound Care
|January 24, 2008
PubMed

Insights

Cardiac dysfunction is prevalent in patients with chronic diabetic foot ulcers, even those without prior heart conditions. Echocardiography screening is suggested for diabetic patients with chronic foot ulcers to detect underlying cardiac issues.

Area of Science:

  • Cardiology
  • Diabetology
  • Vascular Medicine

Background:

  • Diabetic foot ulcers are a serious complication of diabetes mellitus.
  • Cardiovascular disease is a common comorbidity in diabetic patients.

Purpose of the Study:

  • To assess the prevalence and severity of cardiac disease in patients with chronic diabetic foot ulcers.
  • To evaluate the utility of echocardiography in screening for cardiac dysfunction in this population.

Main Methods:

  • Eighty patients with chronic diabetic foot ulcers underwent clinical examination, toe blood pressure measurement, and echocardiography.
  • Data on medical history, including cardiovascular disease, were collected.

Main Results:

  • A high percentage of patients (69%) had a history of myocardial infarction, hypertension, or heart failure.
  • Echocardiography revealed signs of cardiac dysfunction (left ventricular dysfunction, hypertrophy, or diastolic dysfunction) in 78% of patients.
  • Notably, 76% of patients without a prior history of cardiovascular disease showed signs of cardiac dysfunction.

Conclusions:

  • Cardiac dysfunction is frequently observed in patients with chronic diabetic foot ulcers.
  • Echocardiography can serve as a valuable screening tool for cardiac issues in this patient group.
  • Diabetic foot ulcers may indicate underlying cardiac disease, warranting further investigation.
Abstract

Related Concept Videos

Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...