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Protocol for Human Blastoids Modeling Blastocyst Development and Implantation
Published on: August 10, 2022
Conception without the development of a human being
1First Department of Obstetrics and Gynecology, Semmelweis University Faculty of Medicine, Budapest, Hungary.
Journal of Perinatal Medicine
|January 24, 2008
Summary
Gestational trophoblastic neoplasia and parthenogenesis-derived tumors arise from abnormal conception or oocyte activation. These growths, including hydatidiform moles and teratomas, are not considered human beings due to their biparental chromosomal origin.
Area of Science:
- Reproductive biology
- Developmental biology
- Human embryology
Background:
- Certain conceptions result in abnormal growths, not viable embryos or fetuses.
- Gestational trophoblastic neoplasia (GTN) includes hydatidiform moles, invasive moles, and choriocarcinoma.
- Parthenogenesis can lead to human tumors like dermoid cysts and teratomas.
Purpose of the Study:
- To elucidate the generation of abnormal growths from atypical conception and oocyte activation.
- To explain why these growths are not classified as human individuals or beings.
- To establish criteria for defining a human being beyond chromosomal number.
Main Methods:
- Review of existing literature on GTN and parthenogenesis.
- Analysis of developmental pathways leading to abnormal growths.
- Philosophical and biological argumentation on the definition of a human being.
Main Results:
- Gestational trophoblastic neoplasia arises from abnormal conception products.
- Parthenogenesis can result in teratomas and dermoid cysts.
- These abnormal growths lack the biparental chromosomal origin necessary to be considered human beings.
Conclusions:
- The definition of a human being requires biparental chromosomal origin, not solely the correct chromosome number.
- Gestational trophoblastic neoplasia and parthenogenesis-derived tumors are distinct from human individuals.
- Understanding these processes clarifies the biological basis of human individuality.
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