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[Correlation between serum glutathione reductases and bone densitometry values].

M Avitabile1, N E Campagna, G A Magrì

  • 1Laboratorio Centralizzato Corso di Laurea in Odontoiatria, Università degli Studi di Catania.

Bollettino Della Societa Italiana Di Biologia Sperimentale
|October 1, 1991
PubMed
Summary

Low activity of antioxidant systems, like glutathione-reductase, is linked to bone demineralization. This suggests free radicals may play a role in bone density loss.

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Area of Science:

  • Biochemistry
  • Pathology
  • Bone Biology

Background:

  • Free radicals are implicated in numerous human diseases due to their high reactivity.
  • Enzymatic antioxidant systems, such as glutathione-reductase in red blood cells and serum, are crucial for scavenging free radicals.

Purpose of the Study:

  • To investigate the potential role of free radicals in the demineralization of the bone matrix.
  • To explore the relationship between antioxidant system activity and bone density.

Main Methods:

  • Glutathione-reductase activity was measured using a modified Horn's method.
  • Bone density was assessed using densitometric measurements.
  • Correlation between glutathione-reductase levels and bone density was analyzed.

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Main Results:

  • Subjects with lower bone density exhibited reduced glutathione-reductase activity.
  • A direct relationship was observed between decreased antioxidant system activity and bone demineralization.

Conclusions:

  • The findings support a link between diminished antioxidant capacity and bone demineralization.
  • Elevated free radical levels may contribute to the demineralization process in bone.