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Published on: April 1, 2022
[Mortality and morbidity in patients with alcohol and biliary-induced acute pancreatitis]
Anders Møller Andersen1, Srdan Novovic, Annette Kjaer Ersbøll
1Bispebjerg Hospital, Kirurgisk Gastroenterologisk Afdeling K, Købehavn NV.
Introduction:
Acute Pancreatitis (AP) is a serious disease with a high mortality. The main aetiological factors involved in development of AP are alcohol and gallstones. Whether aetiology influences mortality and morbidity in AP is not clarified.
Materials And Methods:
The aim of the present study was to determine if there was a significant difference in mortality in alcohol or biliary-induced AP. We retrospectively analysed data comprising all patients admitted to our department with a first attack of AP registered in a 5-year period (2000-2004).
Results:
A total of 290 patients were included. The 30-day and 1-year mortality risks were 5% and 11% and independent of aetiology. ASA-score and severity of AP had a significant effect on the 30-day mortality risk (OR = 9.2 for ASA-score > 2 and OR = 4.2 for severe AP), while daily use of prescribed medicine and ASA-score had a significant effect on the 1-year mortality risk (OR = 10.4 for medicine and OR = 4.5 for ASA-score > 2). Severe AP was a significant predictor for treatment at the Intensive Care Unit (OR = 26.2), as was daily use of prescribed medicine (OR = 7.3).
Conclusion:
Our data shows that AP is associated with considerable mortality and that there is no significant difference in mortality in relation to alcohol or biliary aetiology.
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