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Coronary Angiography During Ex-Situ Heart Perfusion in a Porcine Model

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Two-step postmortem angiography with a modified heart-lung machine: preliminary results.

Silke Grabherr¹, Erich Gygax, Barbara Sollberger

¹Center of Forensic Imaging and Virtopsy, Institute of Forensic Medicine, University of Bern, Bern, Switzerland. silke.grabherr@chuv.ch

AJR. American Journal of Roentgenology

|January 24, 2008

Summary

This study adapted a minimally invasive postmortem angiography technique for human cadavers, enabling detailed vascular mapping and diagnosis of abnormalities like drug injection sites and occlusions.

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Area of Science:

Forensic pathology
Radiology
Vascular anatomy

Background:

Conventional autopsy methods have limitations in detailed vascular system mapping.
Minimally invasive techniques are needed for enhanced postmortem vascular visualization.

Purpose of the Study:

To adapt and improve a two-step postmortem angiographic technique for human cadavers.
To demonstrate the value of this technique in diagnosing vascular abnormalities.

Main Methods:

Postmortem perfusion of oily liquid using a circulation machine.
Bolus injection of oily contrast agent followed by radiographic imaging.
Pilot study on four human cadavers, perfusing upper or lower extremities.

Main Results:

Successful visualization of the vascular system down to small vessels in all cases.
Identification of vascular abnormalities in three out of four cadavers.
Detection of a venous injection mark and arterial/venous occlusions.

Conclusions:

The described postmortem angiography technique is readily applicable to human cadavers.
Detailed investigation of the vascular system and visualization of abnormalities are achievable.
This method offers significant value for diagnosing vascular pathologies in forensic investigations.