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Published on: May 26, 2022

Treatment of hypertension in diabetes

M E Cooper1, G Jerums, P D Chattington

  • 1Department of Medicine, University of Melbourne, Heidelberg, Australia.

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
|January 24, 2008
PubMed

Insights

Diabetics with hypertension need blood pressure management, targeting below 125/75 mmHg. Angiotensin Converting Enzyme (ACE) inhibitors are a primary treatment, often needing combination therapy for optimal control.

Area of Science:

  • Cardiology
  • Nephrology
  • Endocrinology

Background:

  • Diabetes mellitus (Type I and II) significantly elevates cardiovascular, cerebrovascular, and renal risks.
  • Hypertension is a prevalent comorbidity in diabetic patients, often coexisting with other risk factors.

Purpose of the Study:

  • To outline antihypertensive treatment strategies for patients with diabetes mellitus.
  • To emphasize the importance of achieving specific blood pressure targets in this high-risk population.

Main Methods:

  • Review of current data on hypertension management in diabetic patients.
  • Consideration of lifestyle modifications and pharmacological interventions.

Main Results:

  • Antihypertensive therapy is recommended for blood pressures >130/85 mmHg, aiming for <125/75 mmHg, particularly with microalbuminuria or diabetic nephropathy.
  • Angiotensin Converting Enzyme (ACE) inhibitors are the preferred first-line monotherapy unless contraindicated.
  • Combination therapy (dual or triple) is frequently necessary to reach target blood pressure levels.

Conclusions:

  • Aggressive blood pressure control is crucial for mitigating complications in diabetic patients.
  • A stepwise approach, starting with ACE inhibitors and lifestyle changes, is recommended.
  • Multidrug regimens are often required to achieve therapeutic goals in hypertensive diabetics.

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