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Updated: Jul 8, 2026

A Cell Culture Model of Resistance Arteries
Published on: September 8, 2017
Transglutaminases in vascular biology: relevance for vascular remodeling and atherosclerosis
Erik N T P Bakker1, Adrian Pistea, Ed VanBavel
1Department of Medical Physics, Academic Medical Center, Amsterdam, The Netherlands. n.t.bakker@amc.uva.nl
Abstract:
The transglutaminase (Tgase) family consists of nine known members of whom at least three are expressed in the vascular system: type 1 Tgase, type 2 Tgase and factor XIII. The cross-linking of proteins is a characteristic feature of Tgases, of well-known importance for stabilizing the blood clot and providing mechanical strength to tissues. However, recent data suggest that Tgases play a role in several other processes in vascular biology. These newly discovered areas include endothelial barrier function, small artery remodeling, and atherosclerosis.
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