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Ossifying plexiform tumor: report of two new cases
Sarah N Walsh1, Omar P Sangüeza
1Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. sarahnwalsh@aol.com
The American Journal of Dermatopathology
|January 24, 2008
Summary
Ossifying plexiform tumor, a rare skin lesion, presents with central ossification and occurs exclusively on the digits of adult women. This study details two new cases, aiding in its distinction from other ossifying skin lesions.
Area of Science:
- Dermatopathology
- Skeletal Biology
Background:
- Ossifying plexiform tumor (OPT) is a rare cutaneous lesion.
- Previously described in only one case report, its distinct features require further elucidation.
Observation:
- Two additional cases of OPT in adult women (36 and 76 years old) arising on the finger are presented.
- Clinically, lesions appeared as raised, flesh-colored, "extraosseous" masses (average 1.1 cm).
- Histologically, tumors showed lobules of epithelioid to spindled cells with central mature bone and osteoblasts.
Findings:
- OPT exhibits abundant central ossification, differentiating it from cellular neurothekeoma.
- Lesions have shown no recurrence after surgical excision with limited follow-up (9 and 2 months).
- All reported cases, including these two, have occurred exclusively on the digits of adult women.
Implications:
- Recognition of OPT is crucial for accurate diagnosis and differentiation from other cutaneous ossifying lesions.
- OPT may represent a distinct entity (sui generis) rather than a variant of cellular neurothekeoma.
- Further research can clarify the pathogenesis and classification of this unique tumor.
