Related Experiment Video
Updated: Jul 8, 2026
07:09
The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
Published on: July 16, 2014
Proteomics in neuropathic pain research.
Ellen Niederberger1, Gerd Geisslinger
1Institut für Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt, Frankfurt am Main, Germany. e.niederberger@em.uni-frankfurt.de
Anesthesiology
|January 24, 2008
Summary
Neuropathic pain, often linked to nerve injury, involves complex molecular changes. This review summarizes proteomic studies to identify proteins involved in nerve injury and pain, aiding new therapy development.
Area of Science:
- Neuroscience
- Molecular Biology
- Pain Research
Background:
- Neuropathic pain arises from nerve injury or dysfunction, causing allodynia and hyperalgesia.
- Current pharmacologic treatments for neuropathic pain are often insufficient due to unknown molecular mechanisms.
Purpose of the Study:
- To review and summarize proteomic studies on nerve injury and neuropathic pain.
- To elucidate translational and posttranslational modifications in the nervous system following nerve injury.
Main Methods:
- Analysis of results from various proteomic studies.
- Utilizing different animal neuropathy models to investigate molecular changes.
Main Results:
- Identification of proteins involved in the pathogenesis of nerve injury and neuropathic pain.
- Overview of molecular alterations in the nervous system after nerve injury.
Conclusions:
- Understanding these proteins can clarify pathophysiologic signaling pathways.
- Facilitates the discovery of specific biomarkers for neuropathic pain.
- Promotes the development of novel pain therapies.
Related Concept Videos
01:25Analgesia and Pain Management
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
01:44Nociception
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...