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Related Experiment Videos

The infant Apert skull.

S Kreiborg1, M M Cohen

  • 1Department of Pediatric Dentistry, Royal Dental College, Copenhagen, Denmark.

Neurosurgery Clinics of North America
|July 11, 1991
PubMed
Summary
This summary is machine-generated.

The Apert skull in infants presents a wide midline calvarial defect due to premature coronal suture fusion. This defect closes naturally within 2-4 years as bony islands enlarge and merge.

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Area of Science:

  • Craniosynostosis research
  • Pediatric neurosurgery
  • Developmental biology

Background:

  • Apert syndrome is a genetic disorder characterized by premature fusion of skull sutures.
  • Infantile skull development involves complex processes of bone growth and fusion.
  • Understanding calvarial defects is crucial for diagnosing and managing craniofacial abnormalities.

Observation:

  • Infants with Apert syndrome exhibit a significant midline calvarial defect.
  • This defect spans from the nasal root to the posterior fontanelle, involving sutures like the metopic and sagittal.
  • The coronal suture area shows premature fusion, while other sutures are initially patent.

Findings:

  • The wide calvarial defect gradually closes between 2 and 4 years of age.

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  • Bony islands form in the midline and enlarge, eventually coalescing.
  • Closure occurs without the formation of new suture lines, indicating a unique ossification process.

    • Implications:

    • This natural closure mechanism offers insights into bone regeneration and skull development.
    • Understanding this process may inform surgical interventions for craniosynostosis.
    • Further research can explore the genetic and cellular basis of this distinct bone fusion pattern.