Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Receiver Operating Characteristic Plot01:15

Receiver Operating Characteristic Plot

A ROC (Receiver Operating Characteristic) plot is a graphical tool used to assess the performance of a binary classification model by illustrating the trade-off between sensitivity (true positive rate) and specificity (false positive rate). By plotting sensitivity against 1 - specificity across various threshold settings, the ROC curve shows how well the model distinguishes between classes, with a curve closer to the top-left corner indicating a more accurate model. The area under the ROC curve...
Kaplan-Meier Approach01:24

Kaplan-Meier Approach

The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sexual Function and Libido Loss in Female Climbers-A Cross-Sectional Study.

Sports (Basel, Switzerland)·2026
Same author

A cross-sectional study exploring mental health literacy among non-athlete personnel in elite-level road cycling.

Discover mental health·2026
Same author

Patient acceptance and implementation of micronutrient therapy in women with neurostress-related symptoms.

Archives of gynecology and obstetrics·2026
Same author

Unmet clinical needs in women with polycystic ovary syndrome regarding chronic non-communicable diseases: A cross‑sectional study.

Archives of gynecology and obstetrics·2026
Same author

Micronutrient therapy for pyrroluria: a retrospective analysis of patient acceptance.

Archives of gynecology and obstetrics·2026
Same author

Risks for eating disorder in ultra-endurance athletes and the role of training volume: a cross-sectional study.

Frontiers in sports and active living·2025

Related Experiment Video

Updated: Jul 8, 2026

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

Cut-off-independent tumour marker evaluation using ROC approximation.

Norman Bitterlich1, Joachim Schneider

  • 1Medizin und Service GmbH, Zwickauer Str. 227, D-09116 Chemnitz, Germany.

Anticancer Research
|January 25, 2008
PubMed
Summary

This study introduces Decision Guarantee (DG) for cut-off-independent tumor marker analysis, improving lung cancer diagnosis accuracy. DG offers a reliable, method-independent diagnostic support tool by analyzing receiver operating characteristic (ROC) curves.

Related Experiment Videos

Last Updated: Jul 8, 2026

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

Area of Science:

  • Oncology
  • Medical Diagnostics
  • Biochemistry

Background:

  • Tumor marker analysis relies on cut-off values, leading to variability.
  • Method and reference group changes impact diagnostic results.
  • Cut-off-independent evaluation minimizes laboratory and method-specific errors.

Purpose of the Study:

  • To evaluate the influence of receiver operating characteristic (ROC) curve differences on Decision Guarantee (DG) determination.
  • To establish a cut-off-independent method for laboratory parameter evaluation.
  • To enhance the reliability of tumor marker-based lung cancer diagnosis.

Main Methods:

  • Analysis of 281 lung cancer patients and 231 controls (healthy, lung diseases).
  • Histological classification of lung cancer subtypes.
  • Determination of Decision Guarantee (DG) using ROC curves and a reference population.

Main Results:

  • Cytokeratin-19 fragments (CYFRA 21-1) showed 57.3% sensitivity and 94.9% specificity.
  • The described method, utilizing ROC curves, confirmed lung cancer diagnosis with statistical certainty.
  • Decision Guarantee (DG) enabled a reliable diagnosis independent of specific laboratory methods.

Conclusions:

  • Decision Guarantee (DG) offers a laboratory- and method-independent diagnostic support.
  • Fairer data analysis is achieved by incorporating reference population information.
  • This approach enhances the objectivity and reliability of tumor marker interpretation for lung cancer.