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Related Experiment Videos

Fumaric acid production by fermentation.

Carol A Roa Engel1, Adrie J J Straathof, Tiemen W Zijlmans

  • 1Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC, Delft, The Netherlands.

Applied Microbiology and Biotechnology
|January 25, 2008
PubMed
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Fermentation offers a cost-effective, renewable route to fumaric acid production, utilizing cheaper feedstocks and capturing CO2. Advances in submerged fermentation and metabolic engineering show promise for industrial viability.

Area of Science:

  • Biotechnology
  • Industrial Microbiology
  • Polymer Science

Background:

  • Rising costs of petroleum-based fumaric acid drive interest in renewable production methods.
  • Fumaric acid is a key raw material for the polymer industry.

Purpose of the Study:

  • To review fumaric acid production via fermentation using renewable resources.
  • To assess the economic viability and future prospects of biotechnological fumaric acid synthesis.

Main Methods:

  • Review of fermentation processes using Rhizopus species.
  • Analysis of metabolic pathways involved in fumaric acid production.
  • Evaluation of submerged fermentation coupled with product recovery.

Main Results:

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  • Fermentation yields 85% w/w fumaric acid from glucose, a cheaper feedstock than maleic anhydride.
  • Fermentation processes capture atmospheric CO2.
  • Submerged fermentation systems demonstrate economically attractive yields and productivities.

    • Conclusions:

    • Fermentation presents a sustainable and cost-effective alternative to chemical synthesis for fumaric acid.
    • Metabolic engineering for low pH fermentation is a key area for future improvement.