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Updated: Jul 8, 2026

Manual Segmentation of the Human Choroid Plexus Using Brain MRI
Published on: December 15, 2023
Cystic choroid plexus papilloma with multiple mural nodules in an infant
Parisa Emami-Naeini1, Farideh Nejat, Mostafa El Khashab
1Department of Neurosurgery, Children's Hospital Medical Center, Medical Sciences/University of Tehran, Tehran, Iran.
Insights
A pediatric case highlights a cystic choroid plexus papilloma presenting as increased head circumference and seizures. Complete surgical removal of enhancing nodules is crucial for a cure.
Area of Science:
- Pediatric Neurology
- Neuro-oncology
- Surgical Pathology
Background:
- A 13-month-old male infant presented with progressive macrocephaly, neurodevelopmental delay, and seizures.
- History of increased intracranial pressure due to an arachnoid cyst managed with shunting, but symptoms persisted.
Observation:
- Magnetic resonance imaging revealed an intraventricular cystic tumor.
- The tumor exhibited intensely enhancing mural nodules.
Findings:
- Surgical excision of the cyst and nodules was performed.
- Histopathological analysis confirmed the diagnosis of cystic choroid plexus papilloma.
Implications:
- Emphasizes the need for accurate evaluation of intracranial cystic lesions to avoid misdiagnosis.
- Recommends total resection of enhancing nodules in cystic choroid plexus papilloma for complete tumor cure.
Background:
A case of a 13-month-old male infant with progressive increase in head circumference, neurodevelopmental delay, and episodic generalized seizures is reported. He had a history of increase in intracranial pressure because of an arachnoid cyst at the age of 2 months which was managed by cystoperitoneal shunting, but the symptoms were still progressive.
Discussion:
Magnetic resonance imaging revealed an intraventricular cystic tumor with intensely enhancing mural nodules. He underwent surgery and the cyst with the nodules was totally excised. Histopathological findings confirmed the diagnosis of cystic choroid plexus papilloma.
Conclusion:
We recommend precise evaluation of intracranial cystic lesions to prevent wrong diagnosis and operation. Total resection of all enhancing nodules in cystic choroid plexus papilloma is proposed to warrant total cure of tumor.
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