Related Experiment Video
Updated: Jul 8, 2026
Ex Vivo and In Vivo Animal Models for Mechanical and Chemical Injuries of Corneal Epithelium
Published on: April 6, 2022
Effect of retinol palmitate eye drops on experimental keratoconjunctival epithelial damage induced by n-heptanol in
Hiroshi Toshida1, Akito Odaka, Daisuke Koike
1Department of Ophthalmology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan. toshida@med.juntendo.ac.jp
Purpose:
To investigate ability of vitamin A (VA, retinol palmitate) to promote wound healing after injury in rabbit eye.
Methods:
After keratoconjunctival injury by 20 microL of n-heptanol, VA eye drops at 500, 1000, or 1500 IU/mL were started 6 times a day for 11 days. Fluorescein and rose bengal staining and histological analysis were performed.
Results:
Fluorescein staining was significantly reduced by 1000 and 1500 IU/mL of VA and rose bengal staining by all concentrations. Histological examination revealed acceleration of wound healing after 7 days (1500 IU/mL).
Conclusions:
VA may be useful in treatment of keratoconjunctival injury.
