Gender differences in the diagnosis and treatment of HIV

Many cases of HIV infection in women in the United States are diagnosed very late in the course of their illness. HIV testing should be routinely recommended if a woman presents with certain gynecologic conditions or sexually transmitted diseases. Lack of awareness of HIV status leads to the majority of new sexually transmitted HIV infections. In the United States, most AIDS cases diagnosed among females in 2004 were attributable to high-risk heterosexual contact, disproportionately affecting black and Hispanic women. Depending on the racial/ethnic community being served, obstacles to access to care, including poverty, transportation issues, and cultural and language barriers, must be overcome. The full implications of gender differences in viral load and CD4 count in the treatment of women with HIV are not yet known. Clinical trial data on HIV therapies in women are limited, and most studies that have included women have not been powered to detect gender differences in virologic and immunologic success rates. Timing and choice of treatment are affected by the pharmacokinetics of antiretroviral drugs and the long-term complications of treatment, both of which may be different for men and women with HIV infection.