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Updated: Jul 8, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
cis-Bis(acetato-kappaO)bis(dimethyl sulfide-kappaS)platinum(II)
Christian Hansson1, Ake Oskarsson
1Organic Chemistry, Department of Chemistry, Lund University, PO Box 124, SE-221 00 Lund, Sweden. christian.hansson@organic.lu.se
Abstract:
The title compound, cis-[Pt(CH3COO)2(C2H6S)2], crystallizes in the P2(1)/c space group with a pseudo-square-planar coordination geometry. The complex forms centrosymmetric dimeric packing units, with C-H...O-Pt interactions and a short Pt...Pt distance [3.5868 (2) A]. The coordination mode of the acetate ligands is monodentate and they are oriented almost perpendicular to the coordination plane. Cambridge Structural Database [Allen (2002). Acta Cryst. B58, 380-388] data show a preferred staggered conformation with respect to the coordination plane for Me2S in complexes with Pt(II).
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