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Acanthamoeba keratitis: persistent organisms without inflammation after 1 year of topical chlorhexidine
Patrick Gooi1, Matthew Lee-Wing, Seymour Brownstein
1Department of Ophthalmology, University of Ottawa and The Ottawa Hospital, Ottawa, Ontario, Canada.
Purpose:
To report a non-contact lens wearer with persistent Acanthamoeba organisms in the cornea after being treated with medical therapy that included topical chlorhexidine as 1 agent for 1 year.
Methods:
A 53-year-old man with Acanthamoeba keratitis was treated with medical therapy for >1 year, followed by a penetrating keratoplasty.
Results:
Histopathologic examination of the keratoplasty specimen revealed viable-appearing Acanthamoeba cysts and trophozoites within the deep corneal stroma in a focus of corneal scarring.
Conclusions:
The use of chlorhexidine as 1 agent in the medical management of Acanthamoeba keratitis may not eradicate the organisms.
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