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Updated: Jul 8, 2026

A Mouse Distraction Osteogenesis Model
Published on: November 14, 2018
Relapse following frontofacial advancement using the rigid external distractor
Helen Witherow1, Filip Thiessen, Robert Evans
1Department of Craniofacial Surgery, Great Ormond Street Hospital, London, United Kingdom. Helen.Witherow@blueyonder.co.uk
Frontofacial advancement using distraction osteogenesis is a stable technique for correcting craniofacial hypoplasia. A longer latency period and slower distraction rate improve stability, with overdistraction not needed to compensate for relapse.
Area of Science:
- Craniofacial Surgery
- Orthognathic Surgery
- Pediatric Plastic Surgery
Background:
- Multisutural synostosis can cause frontofacial hypoplasia, impacting aesthetics and function.
- Frontofacial advancement via monobloc or bipartition osteotomy can correct these issues.
- Distraction osteogenesis offers larger, safer advancements than conventional osteotomy but raises stability concerns.
Purpose of the Study:
- To evaluate the stability of frontofacial advancement using distraction osteogenesis with a rigid external distractor system.
- To compare the outcomes of two distraction protocols in patients with craniofacial dysostosis.
Main Methods:
- Retrospective study of 21 patients with craniofacial dysostosis.
- Frontofacial advancement using a rigid external distractor system.
- Two distraction protocols: Protocol 1 (24h latency, 1.5 mm/d) and Protocol 2 (7d latency, 1 mm/d).
- Measurements of frontofacial advancement using lateral cephalograms and 3D CT scans.
Main Results:
- Average midface distraction of 16.4 mm (range 12-22 mm).
- Relapse occurred in only 3 of 21 patients, all treated with Protocol 1.
- Protocol 2 (longer latency, slower rate) demonstrated greater stability.
Conclusions:
- Distraction osteogenesis with a rigid external distractor is generally stable for frontofacial advancement.
- A longer latency period and reduced distraction rate enhance stability.
- Overdistraction is not necessary to account for potential relapse in growing infants.
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