Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Cellular cholesterol trafficking and compartmentalization.

¹Institute of Biomedicine/Anatomy, University of Helsinki, Haartmaninkatu 8, University of Helsinki, Helsinki FI-00014, Finland. elina.ikonen@helsinki.fi

Nature Reviews. Molecular Cell Biology

|January 25, 2008

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

TOM1 family proteins: from cargo sorting to immune dysregulation and cancer.

Cell communication and signaling : CCS·2026

Same author

Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex.

Science (New York, N.Y.)·2025

Same author

A TOM1 variant impairs interaction with TOLLIP, autophagosome-lysosome fusion and regulation of innate immunity.

Disease models & mechanisms·2025

Same author

Control of Golgi- V-ATPase through Sac1-dependent co-regulation of PI(4)P and cholesterol.

Nature communications·2025

Same author

Nuclear envelope-associated lipid droplets are enriched in cholesteryl esters and increase during inflammatory signaling.

The EMBO journal·2025

Same author

Functional omics of ORP7 in primary endothelial cells.

BMC biology·2024

Same journal

How proteins fold.

Nature reviews. Molecular cell biology·2026

Same journal

Single-cell evidence for PANoptosome complexes.

Nature reviews. Molecular cell biology·2026

Same journal

Reply to 'Single-cell evidence for PANoptosome complexes'.

Nature reviews. Molecular cell biology·2026

Same journal

Plucking cellular ribosomes with Ribo-Tweezer.

Nature reviews. Molecular cell biology·2026

Same journal

COPII meets autophagy at the ER membrane.

Nature reviews. Molecular cell biology·2026

Same journal

Diapause presses pause on life's developmental and ageing clock.

Nature reviews. Molecular cell biology·2026

See all related articles

Cholesterol is vital for cell membranes. Understanding its complex cellular handling and whole-body transport offers key insights into cholesterol physiology and trafficking.

Area of Science:

Biochemistry
Cell Biology
Physiology

Background:

Cholesterol is a critical structural component of vertebrate cell membranes.
Cellular cholesterol homeostasis involves complex biophysical and enzymatic processes.
Intracellular and intercellular cholesterol exchange is regulated by signaling and lipid transfer systems.

Purpose of the Study:

To elucidate the mechanisms governing cellular cholesterol handling and exchange.
To explore the role of signaling and lipid transfer systems in cholesterol compartmentalization.
To integrate organelle-level processes with whole-body cholesterol transport.

Main Methods:

Analysis of cholesterol's biophysical properties.
Investigation of cholesterol metabolism enzymology.

Related Experiment Videos

Characterization of cellular signaling and lipid transfer pathways.

Main Results:

Cholesterol's structural role in membranes is fundamental.
Cellular processes dictate cholesterol handling and inter-organelle exchange.
A network of signaling and transfer systems controls lipid compartmentalization.

Conclusions:

Understanding cholesterol's cellular dynamics is crucial for physiology.
The integration of cellular and tissue-level transport provides insights into cholesterol trafficking.
Further research into these pathways can illuminate metabolic disorders.