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Related Concept Videos

Signal Transduction: Overview01:26

Signal Transduction: Overview

Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Cell-surface Signaling01:21

Cell-surface Signaling

Hormones—or any molecule that binds to a receptor, known as a ligand—that are lipid-insoluble (water-soluble) are not able to diffuse across the cell membrane. In order to be able to affect a cell without entering it, these hormones bind to receptors on the cell membrane. When a first messenger, a hormone, binds to a receptor, a signal cascade is set off, causing second messengers, proteins inside the cell, to become activated, resulting in downstream effects.

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Related Experiment Video

Updated: Jul 8, 2026

Lipidomics and Transcriptomics in Neurological Diseases
09:58

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

Lipid signalling in disease.

Matthias P Wymann1, Roger Schneiter

  • 1Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH-4058 Basel, Switzerland. matthias.wymann@unibas.ch

Nature Reviews. Molecular Cell Biology
|January 25, 2008
PubMed
Summary

Signalling lipids regulate crucial cell functions. This review integrates their roles in inflammation, cancer, and metabolic diseases, exploring therapeutic strategies.

Area of Science:

  • Biochemistry and Molecular Biology
  • Cell Biology
  • Physiology

Background:

  • Signalling lipids (e.g., eicosanoids, phosphoinositides, sphingolipids, fatty acids) are vital regulators of cellular processes.
  • Lipid-modifying enzymes are controlled by extracellular signals, forming complex lipid signalling networks.
  • Dysregulation of these lipid networks is implicated in human diseases.

Purpose of the Study:

  • To provide an integrated overview of signalling lipid functions.
  • To highlight the role of lipid signalling in inflammation, cancer, and metabolic disease.
  • To discuss emerging therapeutic interventions targeting lipid signalling.

Main Methods:

  • Literature review and synthesis of current research on signalling lipids and their associated enzymes.

Related Experiment Videos

Last Updated: Jul 8, 2026

Lipidomics and Transcriptomics in Neurological Diseases
09:58

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

  • Analysis of the cross-regulatory mechanisms within lipid signalling networks.
  • Examination of disease pathogenesis linked to lipid signalling imbalances.

    • Main Results:

    • Signalling lipids orchestrate cell proliferation, apoptosis, metabolism, and migration.
    • Key enzymes like phospholipases and kinases modulate lipid mediator production.
    • Complex interactions within the lipid network offer multiple points for therapeutic targeting.

    Conclusions:

    • Signalling lipids are central to cellular homeostasis and disease development.
    • An integrated understanding of lipid signalling is crucial for developing effective therapies.
    • Targeting lipid signalling pathways presents promising therapeutic avenues for inflammatory, cancerous, and metabolic disorders.