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Related Experiment Videos

Reference values for the nickel concentration in human finger nails.

B Gammelgaard1, K Peters, T Menné

  • 1Royal Danish School of Pharmacy, Copenhagen.

Journal of Trace Elements and Electrolytes in Health and Disease
|June 1, 1991
PubMed
Summary

This study establishes a reference range for nickel concentration in fingernails for healthy individuals not exposed to occupational nickel. The findings provide essential data for biomonitoring and understanding normal nickel levels in the general population.

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Area of Science:

  • Environmental Health
  • Toxicology
  • Biomonitoring

Background:

  • Nickel is a common environmental and occupational exposure.
  • Establishing reference values for trace elements in biological samples is crucial for health assessments.
  • Fingernails serve as a useful matrix for long-term exposure monitoring.

Purpose of the Study:

  • To determine a reference value for nickel concentration in fingernails of healthy, non-occupationally exposed individuals.
  • To provide data for biomonitoring and toxicological assessments.
  • To establish population-based reference ranges for nickel in fingernails.

Main Methods:

  • Analysis of nickel concentration in fingernail samples from 95 healthy individuals.
  • Statistical analysis including mean, median, standard deviation, and confidence intervals.

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  • Comparison of nickel levels between genders and correlation with age.

    • Main Results:

    • The mean nickel concentration was 1.19 +/- 1.61 mg/kg, with a median of 0.49 mg/kg.
    • The 95% confidence intervals for the mean and median were 0.51-1.26 mg/kg and 0.39-0.74 mg/kg, respectively.
    • No significant differences in nickel levels were found between men and women, nor was there a correlation with age.

    Conclusions:

    • A reference range for nickel in fingernails for a healthy, non-occupationally exposed population was established.
    • The data supports the use of fingernails as a reliable biomaterial for assessing nickel exposure.
    • These reference values are valuable for clinical and epidemiological studies concerning nickel exposure.