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Exocrine pancreatic function in biliary tract pathology treated with the endoscopic methods.
J Wasielica-Berger1, J W Długosz, W Łaszewicz
1Department of Gastroenterology and Internal Medicine, Medical University of Białystok, Poland.
Advances in Medical Sciences
|January 26, 2008
Summary
Biliary pathology affects pancreatic exocrine function in about one-third of patients. Endoscopic treatment for biliary issues significantly improved pancreatic function in most affected individuals.
Area of Science:
- Gastroenterology
- Pancreatology
- Endoscopic procedures
Background:
- Pancreatic exocrine insufficiency (PEI) is common in biliary tract diseases.
- Approximately 30% of patients with biliary pathology experience PEI.
Purpose of the Study:
- To evaluate pancreatic exocrine function in patients with biliary tract pathology before and after endoscopic treatment.
- To assess the impact of endoscopic treatment on pancreatic function in choledocholithiasis and related complications.
Main Methods:
- Fecal elastase 1 concentration was measured using ELISA in 28 patients with choledocholithiasis.
- Measurements were taken before, early after, and 6-8 weeks after endoscopic treatment.
- Pancreatic inflammatory response was also monitored.
Main Results:
- Initially, 32% of patients exhibited low fecal elastase 1 concentrations, indicating impaired pancreatic exocrine function.
- Endoscopic treatment was successful in 82% of cases with minimal pancreatic inflammation.
- In patients with initially low fecal elastase 1, pancreatic function significantly improved (median 310 microg/g) after treatment (P < 0.001).
Conclusions:
- A significant proportion of patients with biliary pathology present with pancreatic exocrine dysfunction.
- Endoscopic treatment of biliary tract pathology can lead to a substantial improvement in exocrine pancreatic function.
- Endoscopic therapy offers a dual benefit by resolving biliary issues and ameliorating pancreatic dysfunction.
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