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Related Concept Videos

Other Disorders of Digestive System01:30

Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

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Related Experiment Video

Updated: Jul 8, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Celiac disease.

R John Presutti1, John R Cangemi, Harvey D Cassidy

  • 1Department of Family Medicine, Mayo Clinic, Jacksonville, Florida 32224, USA.

American Family Physician
|January 26, 2008
PubMed
Summary
This summary is machine-generated.

Celiac disease affects 1 in 100-200 people and is an immune response to gluten. Diagnosis involves antibody testing and biopsy, with a gluten-free diet as the primary treatment.

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Chronic Salmonella Infection Induced Intestinal Fibrosis

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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Area of Science:

  • Gastroenterology
  • Immunology
  • Internal Medicine

Background:

  • Celiac disease is an immune reaction to gluten affecting 1-2% of the US population.
  • Manifestations vary from asymptomatic to severe malabsorption and increased cancer risk.
  • Accurate diagnosis is crucial for effective management and preventing complications.

Purpose of the Study:

  • To outline diagnostic approaches for celiac disease.
  • To emphasize the importance of a gluten-free diet in management.
  • To highlight associated health conditions requiring monitoring.

Main Methods:

  • Initial diagnostic testing involves serum immunoglobulin A (IgA) tissue transglutaminase (tTG) antibodies.
  • Positive results warrant small bowel biopsy for confirmation.
  • Consider serum total IgA levels if IgA tTG is negative in high-suspicion cases.

Main Results:

  • Serum IgA tTG offers adequate sensitivity and specificity for celiac disease screening.
  • IgA deficiency occurs in 3% of celiac patients, necessitating alternative testing considerations.
  • A gluten-free diet typically resolves symptoms within months.

Conclusions:

  • Early diagnosis and adherence to a gluten-free diet are key to managing celiac disease.
  • Regular monitoring for associated conditions like osteoporosis and deficiencies is essential.
  • Serum IgA tTG levels can serve as a marker for treatment adherence.