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Related Experiment Video

Updated: Jul 8, 2026

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Published on: February 16, 2022

CO and NO in medicine.

Brian E Mann¹, Roberto Motterlini

¹Department of Chemistry, University of Sheffield, Sheffield, UK. b.mann@sheffield.ac.uk

Chemical Communications (Cambridge, England)

|January 26, 2008

Summary

Carbon monoxide (CO) and nitric oxide (NO) are vital signaling molecules in biology. This review covers their synthesis, targets, physiological effects, and therapeutic applications in medicine, focusing on controlled in vivo generation.

Area of Science:

Biochemistry
Physiology
Pharmacology

Background:

Carbon monoxide (CO) and nitric oxide (NO) are gaseous molecules with significant biological roles.
Their endogenous production and signaling pathways are crucial for various physiological processes.

Purpose of the Study:

To review the occurrence, roles, and consequences of CO and NO in biological systems.
To discuss their medical applications and delivery methods, emphasizing in vivo generation.

Main Methods:

Literature review of CO and NO in biological systems.
Analysis of synthesis pathways (heme oxygenases, NO synthases).
Examination of biological targets and physiological effects.

Main Results:

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CO and NO are synthesized by specific enzymes and act on diverse biological targets.
They exert significant physiological effects as signaling molecules.
Therapeutic strategies involve controlled in vivo generation of CO and NO.

Conclusions:

CO and NO are critical endogenous signaling molecules with broad physiological relevance.
Their therapeutic potential is being actively explored through innovative delivery systems for controlled in vivo release.