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Mortality in multiple sclerosis: a review.

P Ragonese1, P Aridon, G Salemi

  • 1Dipartimento Universitario di Neuroscienze Cliniche, Università di Palermo, Palermo, Italy.

European Journal of Neurology
|January 26, 2008
PubMed
Summary
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Mortality in multiple sclerosis (MS) patients is only slightly elevated compared to the general population. Increased mortality risk is observed in older individuals and those with longer disease duration.

Area of Science:

  • Neurology
  • Epidemiology
  • Public Health

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease with variable prognosis.
  • Understanding MS-related mortality is crucial for clinical practice and public health strategies.

Purpose of the Study:

  • To evaluate existing studies on mortality in multiple sclerosis (MS).
  • To determine if survival study inferences can be applied to clinical practice.
  • To analyze trends in MS prognosis and causes of death.

Main Methods:

  • Conducted a literature search for epidemiological studies on MS prognosis, survival, and mortality.
  • Included World Health Organization (WHO) cause-specific mortality reports.
  • Evaluated studies based on follow-up duration, publication year, and methodology.

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Main Results:

  • Mortality in MS patients is only slightly higher than in the general population.
  • Older MS patients and those with longer disease duration exhibit higher mortality rates.
  • Methodological evaluation considered time trends in MS survival.

Conclusions:

  • Mortality in multiple sclerosis (MS) is not significantly elevated overall.
  • Clinical practice can benefit from survival data, particularly for specific patient subgroups.
  • Further research into long-term survival trends and causes of death in MS is warranted.