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Updated: Jul 8, 2026
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The Bovine Lung in Biomedical Research: Visually Guided Bronchoscopy, Intrabronchial Inoculation and In Vivo Sampling Techniques
Published on: July 3, 2014
Pasteurella multocida and bovine respiratory disease.
S M Dabo1, J D Taylor, A W Confer
1Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078-2007, USA.
Animal Health Research Reviews
|January 26, 2008
Summary
Pasteurella multocida serogroup A causes bovine respiratory disease. High antibody levels to outer membrane proteins may improve cattle resistance, but vaccine efficacy needs more research.
Area of Science:
- Veterinary Microbiology
- Bacterial Pathogenesis
- Immunology
Background:
- Pasteurella multocida (P. multocida) is a significant Gram-negative bacterial pathogen.
- Serogroup A isolates are common causes of bovine respiratory disease (BRD), including enzootic calf pneumonia and shipping fever.
- P. multocida A:3 is the most frequent serotype implicated in BRD.
Purpose of the Study:
- To review the pathogenesis and immune response to P. multocida in cattle.
- To evaluate the role of outer membrane proteins (OMPs) in immunity.
- To assess current P. multocida vaccines and identify knowledge gaps.
Main Methods:
- Literature review of P. multocida pathogenesis, virulence factors, and host immunity.
- Analysis of bacterial characteristics, including outer membrane protein profiles and ribotyping.
- Examination of available vaccine strategies and their documented efficacy.
Main Results:
- P. multocida infection in cattle is linked to stress and viral co-infections.
- Virulence factors include adherence factors, iron acquisition proteins, enzymes, LPS, capsule, and OMPs.
- High serum antibodies against OMPs are associated with enhanced resistance to P. multocida.
Conclusions:
- Immunity against bovine respiratory pasteurellosis is not fully understood.
- OMPs are potential targets for improving vaccine-induced resistance.
- Current P. multocida vaccines (bacterins, live mutants) have poorly documented field efficacy.
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