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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

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[Hepatic involvement in celiac disease].

Almudena Barbero Villares¹, José Andrés Moreno Monteagudo, Ricardo Moreno Borque

¹Servicio de Aparato Digestivo, Unidad de Hepatología, Hospital Universitario de La Princesa, Universidad Autónoma, Madrid, España. albavi79@hotmail.com

Gastroenterologia Y Hepatologia

|January 26, 2008

Summary

This summary is machine-generated.

Celiac disease (CD) can cause elevated liver enzymes in many patients. A gluten-free diet often resolves these liver issues, highlighting the importance of testing for CD in cases of unexplained liver dysfunction.

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Area of Science:

Gastroenterology and Hepatology
Immunology

Context:

Celiac disease (CD) is an autoimmune disorder triggered by gluten.
Liver dysfunction, including hypertransaminasemia, is frequently observed in untreated CD patients.

Purpose:

To explore the association between celiac disease and liver abnormalities.
To recommend diagnostic approaches for patients with CD and liver issues, and vice versa.

Summary:

Hypertransaminasemia occurs in up to 40% of untreated celiac patients and typically improves with a gluten-free diet.
Non-specific reactive hepatitis is the most common liver finding in CD, though associations with other liver diseases exist.
Testing for CD is advised in patients with unexplained hypertransaminasemia or cholestasis, and liver function should be assessed in CD patients.

Impact:

Highlights the gastrointestinal-liver axis in celiac disease.
Provides clinical guidance for diagnosing and managing liver complications in celiac disease.
Emphasizes the importance of considering celiac disease in patients presenting with liver dysfunction of unknown origin.