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Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
Cholestatic jaundice as the predominant presentation in a patient with autoimmune hepatitis
Chia-Pei Tang1, Yih-Tsong Shiau, Yi-Hsiang Huang
1Division of Gastroenterology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, Repblic of China.
Abstract:
Autoimmune hepatitis is a heterogeneous liver disease of unknown etiology. It is predominant in females and characterized by elevation of transaminase, hypergammaglobulinemia and circulating autoantibodies. Interface hepatitis and plasma cell infiltration are the main findings on liver biopsy. However, deep cholestatic jaundice is rarely seen. We present here an unusual case of type 1 autoimmune hepatitis with hyperbilirubinemia as the initial and predominant presentation. Although rare, autoimmune hepatitis should be considered in patients with cholestasis without history of drug or viral hepatitis.
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