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A discrete view on fold space.

Manfred J Sippl1, Stefan J Suhrer, Markus Gruber

  • 1Center of Applied Molecular Engineering, Division of Bioinformatics, Department of Molecular Biology, University of Salzburg, Hellbrunnerstr. 34, 5020 Salzburg, Austria. sippl@came.sbg.ac.at

Bioinformatics (Oxford, England)
|January 26, 2008
PubMed
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Discovering protein structural similarities is crucial for understanding biological relationships. The Fold Space Navigator provides a new tool for efficiently navigating protein structures and visualizing these similarities.

Area of Science:

  • Structural biology
  • Bioinformatics
  • Computational biology

Background:

  • Protein structure databases contain numerous similarities.
  • Identifying and comprehending these similarities is challenging.
  • Effective visualization is needed for understanding protein relationships.

Purpose of the Study:

  • Introduce a novel user interface for exploring protein structures.
  • Enable efficient navigation through 'fold space'.
  • Facilitate instantaneous visualization of pairwise protein structure similarities.

Main Methods:

  • Development of the Fold Space Navigator interface.
  • Implementation of algorithms for detecting structural similarities.
  • Web service accessibility for public use.

Related Experiment Videos

Main Results:

  • The Fold Space Navigator allows users to navigate protein structural data.
  • Pairwise structure similarities can be visualized instantly.
  • The tool aids in uncovering biological relationships through structural comparison.

Conclusions:

  • The Fold Space Navigator simplifies the exploration of protein structural data.
  • It enhances the ability to identify and understand biological relationships.
  • This tool is publicly available as a web service.