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[Insulin/glucagon relationship in spontaneous diabetic remission]
J C Cresto1, J M Sires, O Ramos
1Unidad de Endocrinología, Hospital General de Niños Dr. Pedro de Elizalde, Buenos Aires.
Medicina
|January 1, 1991
Summary
Children in diabetic remission show impaired insulin secretion and glucose metabolism. This suggests underlying issues persist even after blood glucose normalization.
Area of Science:
- Pediatric Endocrinology
- Metabolic Disorders
- Diabetes Mellitus Research
Background:
- Diabetic remission is defined as symptom resolution and normalized blood glucose post-insulin withdrawal.
- Understanding the metabolic profile of children in diabetic remission is crucial for long-term management.
Purpose of the Study:
- To investigate glucose metabolism and hormone secretion in insulin-dependent diabetic children in remission.
- To compare these parameters with those of healthy, age-matched controls.
Main Methods:
- Studied 21 children in diabetic remission and 29 healthy controls.
- Administered intravenous glucose tolerance tests (IVGT) and glucose post-tolbutamide tests (PTGT).
- Measured glucose, insulin, C-peptide, glucagon, and somatotropin levels.
Main Results:
- Children in remission exhibited significantly lower insulin and C-peptide secretion during IVGT compared to controls.
- The glucose disappearance rate ("K" value) was lower in the remission group.
- Post-tolbutamide stimulation revealed diminished insulin response and higher glucose levels in the remission group.
Conclusions:
- Children in diabetic remission demonstrate persistent defects in insulin secretion and glucose disposal.
- These findings highlight ongoing metabolic challenges despite clinical remission in pediatric diabetes.