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Related Experiment Video

Updated: Jul 8, 2026

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
12:17

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Published on: August 2, 2017

The IGF axis and placental function. a mini review.

Karen Forbes1, Melissa Westwood

  • 1Maternal and Foetal Health Research Group, University of Manchester, St Mary's Hospital, Manchester, UK.

Hormone Research
|January 26, 2008
PubMed
Summary
This summary is machine-generated.

The insulin-like growth factor (IGF) axis regulates fetal growth, potentially via placental development. This review examines IGFs, binding proteins, and receptors in the placenta and their cellular mechanisms.

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Area of Science:

  • Endocrinology
  • Developmental Biology
  • Reproductive Biology

Background:

  • The insulin-like growth factor (IGF) axis is crucial for fetal growth.
  • IGF-I and IGF-II may influence fetal growth by affecting placental development and function.

Purpose of the Study:

  • To review the expression and roles of IGF axis components in the placenta.
  • To discuss the cellular mechanisms underlying IGF actions in placental development.

Main Methods:

  • Literature review of placental expression and function of IGF axis components.
  • Analysis of cellular mechanisms mediating IGF effects.

Main Results:

  • IGF axis components are expressed in the placenta.
  • IGF binding proteins regulate IGF interaction with the type 1 IGF receptor.
  • These interactions are postulated to influence placental development and function.

Conclusions:

  • The IGF axis plays a significant role in regulating fetal growth through placental development.
  • Understanding these mechanisms is key to comprehending fetal growth regulation.