Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Urinary acidification by furosemide test].

L C Alvarado1, L E Voyer, G Bortolazzo

  • 1Unidad de Nefrología, Hospital General de Niños Pedro de Elizalde, Buenos Aires, Argentina.

Medicina
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adenosine A<sub>1</sub> and A<sub>2a</sub> receptors modulate the nitrergic system in cell culture from dorsomedial medulla oblongata.

Autonomic neuroscience : basic & clinical·2020
Same author

Bioactive compounds from extra virgin olive oils: Correlation between phenolic content and oxidative stress cell protection.

Biophysical chemistry·2017
Same author

Integrated Analyses of Cuticular Hydrocarbons, Chromosome and mtDNA in the Neotropical Social Wasp Mischocyttarus consimilis Zikán (Hymenoptera, Vespidae).

Neotropical entomology·2017
Same author

The endocannabinoid system: A novel player in human placentation.

Reproductive toxicology (Elmsford, N.Y.)·2016
Same author

The endocannabinoid 2-arachidonoylglycerol dysregulates the synthesis of proteins by the human syncytiotrophoblast.

Biochimica et biophysica acta·2015
Same author

Compact low-cost detection electronics for optical coherence imaging.

Optical engineering (Redondo Beach, Calif.)·2015

Furosemide effectively differentiates distal renal tubular acidosis (RTA) from proximal RTA by altering urinary pH and acid excretion. Healthy children and proximal RTA patients show significant urinary acidification, unlike distal RTA patients.

Area of Science:

  • Pediatric Nephrology
  • Renal Physiology
  • Acid-Base Balance

Context:

  • Renal tubular acidosis (RTA) is a disorder affecting the kidneys' ability to excrete acid.
  • Distinguishing between distal RTA and proximal RTA is crucial for appropriate management.
  • Furosemide is a diuretic that can influence renal tubular transport.

Purpose:

  • To investigate the effect of furosemide on urinary acidification in children with healthy kidneys and different types of RTA.
  • To assess furosemide's utility in differentiating between normokalemic distal RTA and proximal RTA.

Summary:

  • Furosemide administration (2 mg/kg orally) was studied in healthy children, patients with distal RTA, and a patient with proximal RTA.
  • Healthy children and the patient with proximal RTA demonstrated a significant decrease in urinary pH and increased ammonia excretion after furosemide.

Related Experiment Videos

  • Patients with distal RTA showed a limited response, with furosemide failing to lower urine pH significantly or increase net acid excretion.

    • Impact:

    • Furosemide serves as a valuable diagnostic tool for distinguishing between distal and proximal RTA in pediatric patients.
    • The differential response to furosemide highlights distinct pathophysiological mechanisms in different RTA subtypes.
    • This study provides evidence for a non-invasive method to aid in RTA diagnosis.