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The reverse stop-signal model for CTLA4 function.
1Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, CB1 4QP Cambridge, UK. cer51@cam.ac.uk
Nature Reviews. Immunology
|January 26, 2008
Summary
Cytotoxic T-lymphocyte antigen 4 (CTLA4) regulates T-cell activation and prevents autoimmunity. A new "reverse stop-signal model" is proposed to better explain CTLA4
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