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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

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Related Experiment Video

Updated: Jul 8, 2026

An In Vitro Model for Studying Tau Aggregation Using Lentiviral-mediated Transduction of Human Neurons
05:51

An In Vitro Model for Studying Tau Aggregation Using Lentiviral-mediated Transduction of Human Neurons

Published on: May 23, 2019

Retinal tau pathology in human glaucomas.

Neeru Gupta1, Jessica Fong, Lee C Ang

  • 1Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, Ontario, Canada. guptan@smh.toronto.on.ca

Canadian Journal of Ophthalmology. Journal Canadien D'Ophtalmologie
|January 26, 2008
PubMed
Summary

Abnormal tau protein (AT8), a marker of neurological injury, is found in human glaucoma retinas, suggesting shared disease pathways with other neurodegenerative conditions.

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In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
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In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
09:22

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Cell Biology

Background:

  • Tau protein is crucial for neuron structure; abnormal hyperphosphorylated tau (AT8) is linked to neurodegeneration in diseases like Alzheimer's.
  • AT8 disrupts microtubules and axonal transport, contributing to neuron injury.

Purpose of the Study:

  • To investigate the presence of tau protein and abnormal tau AT8 in human glaucoma.
  • To determine if abnormal tau protein contributes to neural degeneration in glaucoma.

Main Methods:

  • Immunostaining of surgical glaucoma and control eye specimens for normal tau (BT2) and abnormal tau (AT8).
  • Quantitative immunofluorescence to compare AT8 levels in glaucoma and control retinas.
  • Double-immunofluorescence to assess colocalization of AT8 with parvalbumin in retinal horizontal cells.

Main Results:

  • Normal tau protein was decreased in glaucoma specimens compared to controls.
  • Abnormal tau AT8 was significantly increased in surgical glaucoma retinas, particularly in the inner nuclear layer.
  • Abnormal tau AT8 colocalized with parvalbumin in retinal horizontal cells.

Conclusions:

  • Abnormal tau AT8 is present in human glaucoma, indicating neural injury.
  • The presence of AT8 in retinal horizontal cells may be linked to elevated intraocular pressure and glaucomatous degeneration.
  • Tau protein abnormalities in glaucoma suggest common pathological mechanisms with other neurodegenerative diseases.