Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sulfur Assimilation01:20

Sulfur Assimilation

Sulfur is an essential element in biological systems, contributing to synthesizing key biomolecules, including amino acids such as cysteine and methionine, and cofactors such as coenzyme A and biotin. Microorganisms primarily assimilate sulfur as sulfate (SO₄²⁻) from the environment, which must undergo a series of biochemical transformations before it can be incorporated into cellular components. As sulfate is highly oxidized, it must undergo assimilatory sulfate reduction to become...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological Memory01:23

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Iron and selenium: At the crossroads of development and death in oligodendrocytes.

Archives of biochemistry and biophysics·2025
Same author

Insights from selenoprotein I mouse models for understanding biological roles of this enzyme.

Archives of biochemistry and biophysics·2025
Same author

Methylseleninic Acid Elevating the Nrf2-GPX4 Axis Relieves Endothelial Dysfunction and Ferroptosis Induced by Arsenic Exposure.

Journal of agricultural and food chemistry·2025
Same author

RAIN: a multistate research alliance to facilitate collaboration, increase student opportunities, and share core facility resources.

Advances in physiology education·2025
Same author

Zinc-limited <i>Mycobacterium tuberculosis</i> stimulate distinct responses in macrophages compared with standard zinc-replete bacteria.

Infection and immunity·2025
Same author

Mannose coated selenium nanoparticles normalize intestinal homeostasis in mice and mitigate colitis by inhibiting NF-κB activation and enhancing glutathione peroxidase expression.

Journal of nanobiotechnology·2024

Related Experiment Video

Updated: Jul 8, 2026

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
10:21

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Mechanisms by which selenium influences immune responses.

Peter R Hoffmann1

  • 1Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI 96813, USA. peterh@pbrc.hawaii.edu

Archivum Immunologiae Et Therapiae Experimentalis
|January 26, 2008
PubMed
Summary

Selenium (Se) is vital for immune function, impacting inflammation and immune cell activity. Understanding selenoproteins is key to optimizing immune responses through this essential trace element.

Related Experiment Videos

Last Updated: Jul 8, 2026

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
10:21

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Area of Science:

  • Immunology
  • Nutritional Science
  • Biochemistry

Background:

  • Selenium (Se) is an essential trace element crucial for human health.
  • It is incorporated into selenoproteins as selenocysteine, influencing various biological processes.
  • Immune responses and inflammation are significantly modulated by selenium.

Purpose of the Study:

  • To review the mechanisms by which selenium affects inflammation and immune responses.
  • To examine the role of selenium in phagocyte and lymphocyte functions.
  • To explore the functions of selenoproteins in regulating oxidative stress in leukocytes.

Main Methods:

  • Literature review of existing data on selenium's role in immunity.
  • Analysis of selenium's impact on phagocytes, including activation and function.
  • Examination of selenium's effects on lymphocyte activation, proliferation, and differentiation.
  • Investigation of selenoprotein functions in regulating reactive oxygen species and redox potential.

Main Results:

  • Selenium influences phagocyte activity and function.
  • Selenium affects lymphocyte activation, proliferation, and differentiation.
  • Selenoproteins play a role in regulating reactive oxygen species and redox balance in leukocytes.
  • Specific mechanisms of selenium's immunomodulatory effects are being elucidated.

Conclusions:

  • Selenium is a critical factor in maintaining optimal immune responses.
  • Further research into selenoprotein mechanisms is needed to fully understand selenium's role in immunity and inflammation.
  • Elucidating these mechanisms will enhance strategies for immune health and disease management.