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Published on: March 3, 2023
[Local ablation therapy combined with liver resection for multiple hepatocellular carcinomas]
Toshiro Masuda1, Toru Beppu, Takatoshi Ishiko
1Dept. of Gastroenterological Surgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|January 29, 2008
Summary
For multiple hepatocellular carcinomas (HCCs), combining liver resection with local ablation therapy offers benefits. This approach may lead to reduced resected liver volume and shorter operation times compared to resection alone.
Area of Science:
- Hepatobiliary Surgery
- Surgical Oncology
- Gastroenterology
Background:
- Multiple hepatocellular carcinomas (HCCs) present unique treatment challenges.
- Surgical resection is a primary treatment modality for HCC.
- The role of combined therapies for multifocal HCC requires further investigation.
Purpose of the Study:
- To evaluate the efficacy and safety of combining liver resection with local ablation therapy for multiple HCCs.
- To compare outcomes between liver resection alone and combined therapy in patients with multifocal HCC.
- To assess differences in surgical parameters and oncological results between the two treatment groups.
Main Methods:
- A retrospective study of 63 patients with multiple HCCs without vascular invasion.
- Patients were divided into two groups: liver resection alone (n=27) and combined liver resection and local ablation therapy (n=36).
- Comparison of baseline characteristics, surgical procedures, intraoperative details, and oncological outcomes including disease-free survival and survival rates.
Main Results:
- No significant differences in patient demographics, tumor characteristics, bleeding, transfusion rates, disease-free survival, or survival rates were observed between the groups.
- The combination therapy group demonstrated a significantly lower resected liver volume (p = 0.003) and a shorter operation time (p = 0.009).
- Specific surgical procedures varied, with different distributions of hemihepatectomies, sectionectomies, and partial hepatectomies between the groups.
Conclusions:
- The combination of liver resection and local ablation therapy is a potentially useful strategy for managing multiple hepatocellular carcinomas.
- This combined approach may offer advantages in terms of reduced surgical burden, indicated by lower resected liver volume and shorter operative times.
- Further prospective studies are warranted to confirm these findings and optimize treatment protocols for multifocal HCC.
