[The evaluation of iron exchange parameters in patients with coronary atherosclerosis and type 2 diabetes mellitus]

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Evaluation of Hydration Status by Bioelectrical Impedance Vector Analysis in Patients with Ischemic Heart Disease Undergoing Exercise Stress Test
10:21

Evaluation of Hydration Status by Bioelectrical Impedance Vector Analysis in Patients with Ischemic Heart Disease Undergoing Exercise Stress Test

Published on: September 22, 2023

S G Gorokhova, M A Atamanova, E V Muraseeva

    Klinicheskaia Meditsina
    |January 29, 2008
    PubMed

    Insights

    Patients with coronary artery disease (CAD) and diabetes mellitus (DM) exhibit altered iron metabolism, with lower serum iron and higher ferritin levels, especially with ischemic changes and severe coronary lesions.

    Area of Science:

    • Cardiology
    • Biochemistry
    • Metabolic Disorders

    Context:

    • Coronary artery disease (CAD) is a significant global health concern.
    • Diabetes mellitus (DM) is a common comorbidity in CAD patients.
    • Iron metabolism plays a crucial role in cardiovascular health.

    Purpose:

    • To investigate iron metabolism in patients with coronary artery disease (CAD).
    • To assess the influence of ischemic changes and coronary artery (CA) lesion severity on iron parameters.
    • To compare iron metabolism between CAD patients with and without diabetes mellitus (DM).

    Summary:

    • Serum iron (SI), transferrin, and total iron-binding serum ability (TIBSA) were lower in CAD patients with ischemic electrocardiogram (ECG) signs.
    • Patients with CAD and DM showed significantly lower SI and higher ferritin levels compared to those without DM.
    • Higher ferritin levels correlated with multivascular coronary lesions and were more pronounced in diabetic patients.

    Impact:

    • Findings highlight the complex interplay between iron metabolism, ischemia, and diabetes in CAD.
    • Altered iron profiles may serve as potential biomarkers for disease severity and progression in CAD patients.
    • This research contributes to understanding the metabolic disturbances in comorbid CAD and DM.

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