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Herpes

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Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...

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Related Experiment Video

Updated: Jul 8, 2026

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Published on: December 18, 2012

[Severe herpetic infection].

N A Didkovskiĭ, I K Malashnkova, A N Tanasova

Terapevticheskii Arkhiv

|January 29, 2008

Summary

Severe herpetic simplex infection (HSI) in patients often indicates a compromised immune system, leading to increased susceptibility to other infections. This study highlights immune deficiencies in HSI patients.

Area of Science:

Virology
Immunology
Dermatology

Context:

Herpetic simplex infection (HSI) can manifest severely, particularly in anogenital and labial regions.
Understanding the immune response in severe HSI is crucial for effective management and treatment strategies.
The prevalence and potential co-infection with other viral strains in severe HSI cases require investigation.

Purpose:

To investigate the antiviral defense mechanisms in patients experiencing severe anogenital and labial herpetic infections.
To determine the prevalence of herpetic infection and identify potential co-infections with other viral strains.
To assess the immune status of patients with severe Herpetic Simplex Infection (HSI).

Summary:

A study of 102 patients with severe HSI examined immune status, including lymphocyte subpopulations, immunoglobulins (IgA, IgM, IgG), immune complexes, cytokines, interferon, and neutrophil function.

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Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

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Ex Vivo Organotypic Corneal Model of Acute Epithelial Herpes Simplex Virus Type I Infection

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Results indicated that 70% of severe HSI patients exhibited significant deficiencies and hyporeactivity in natural and/or specific cytotoxicity.

Severe HSI is characterized by combined secondary immunodeficiency, complications, and active mixed viral infections.

Impact:

Identifies severe HSI as a condition linked to significant immune system impairment.
Suggests that severe HSI patients may benefit from comprehensive immunomodulatory therapies.
Highlights the need for further research into managing mixed viral infections in immunocompromised individuals.