Related Experiment Video
Updated: Jul 8, 2026

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method
Published on: February 2, 2024
[Ventilatory and gas exchange functions of the lungs in occupational and other pulmonary diseases]
Aim:
To study lung ventilation and gas exchange in interstitional and obstructive diseases of dust-induced and non-occupational origin for correction of pulmonary diseases.
Material And Methods:
Diffuse lung capacity (Erich Jaeger unit) and biomechanical properties of the ventilation system (total plethysmography on the bodyplethysmograph made by Erich Jaeger) were investigated in 132 patients including 87 with occupational dust-induced pulmonary diseases (pneumoconiosis, dust bronchitis, exogenic allergic alveolitis, bronchial asthma) and 45 patients with non-occupational diseases: sarcoidosis (n = 28), exogenic allergic alveolitis (n = 10) and bronchial asthma (n = 7).
Results:
The changes were of the same type but different severity. Diffuse capacity was subnormal in all the groups, most of all in patients with exogenic allergic alveolitis and sarcoidosis of stage 2-4. In patients with occupational diseases DLCO was reduced, residual volume, total lung capacity were elevated, they had hypoxemia.
Conclusion:
The changes in patients with dust-induced diseases of the lungs may be interpreted primarily as disorders of distribution, imbalance between ventilation and perfusion. Diffusion disorders in patients with alveolitis and sarcoidosis correlated with changes in alveolar-capillary membrane.
More Related Videos
07:09Assessment of Pulmonary Capillary Blood Volume, Membrane Diffusing Capacity, and Intrapulmonary Arteriovenous Anastomoses During Exercise
Published on: February 20, 2017
08:25Combining Volumetric Capnography And Barometric Plethysmography To Measure The Lung Structure-function Relationship
Published on: January 8, 2019
Related Concept Videos
Physiology of Respiration I: Functions of the Respiratory System
Fundamental Processes in Respiration:
Respiration and Gaseous Exchange
Respiration involves the exchange of gases, especially oxygen (O2) and carbon dioxide (CO2), between the alveoli and body cells, a process facilitated by blood circulation. As a result, the cardiovascular system, which involves the...
Physiological Control of Respiration
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
Gas Exchange and Transport
Factors Affecting Pulmonary Ventilation
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Pulmonary Cycle: Exhalation