Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Drugging endosomal flux.

Nature chemical biology·2026

Same author

Valorization of Zingiber officinale Roscoe leaf biomass: phytotoxic potential and chemical profiling toward sustainable weed management.

Journal of the science of food and agriculture·2026

Same author

Harmonized <sup>1</sup>H NMR Workflow Enables Quantitative Betaine Determination from Nontargeted Metabolite Profiling Using Internal and External Standards<sup>‡‡‡‡‡</sup>.

Analytical chemistry·2026

Same author

Statistical Investigation and Optimization of Starch Cinnamylation: A Design of Experiment Approach.

ACS omega·2026

Same author

Cinnamon Bud Extract Is a Source of Biomolecules Active against the Aggregation and Condensation of Alzheimer's-Associated Tau Protein.

Journal of agricultural and food chemistry·2026

Same author

Sugar-Based Polyesters: From Glux-Diol Synthesis to Its Enzymatic Polymerization.

ACS omega·2026

Search research articles

Related Experiment Video

Updated: Jul 8, 2026

Glycan Node Analysis: A Bottom-up Approach to Glycomics

Glycan Node Analysis: A Bottom-up Approach to Glycomics

Published on: May 22, 2016

Glycoconjugates in cancer therapy.

Laura Cipolla¹, Francesco Peri, Cristina Airoldi

¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, P.za della Scienza 2, 20126 Milano, Italy. laura.cipolla@unimib.it

Anti-Cancer Agents in Medicinal Chemistry

|January 29, 2008

Summary

This review explores recent advances in creating glycoconjugate vaccines targeting cancer-associated carbohydrate antigens. These vaccines link carbohydrate antigens with T-cell epitopes to stimulate an immune response against tumors.

Related Experiment Videos

Last Updated: Jul 8, 2026

Glycan Node Analysis: A Bottom-up Approach to Glycomics

Glycan Node Analysis: A Bottom-up Approach to Glycomics

Published on: May 22, 2016

Area of Science:

Carbohydrate Chemistry
Immunology
Vaccine Development
Cancer Therapeutics

Background:

Transformed cells express unique carbohydrate antigens.
Glycoconjugates can elicit an immune response against cancer.
Targeting tumor-associated carbohydrate antigens is a promising strategy.

Purpose of the Study:

To review recent advancements in glycoconjugate synthesis for cancer vaccines.
To evaluate the immunological investigation of tumor-associated carbohydrate antigens.
To consider novel glycoconjugate structures for anti-tumor therapeutics.

Main Methods:

Synthesis of glycoconjugates presenting tumor-associated carbohydrate antigens.
Immunological evaluation of these glycoconjugates.
Review of clustered glycoconjugates, including multiple antigenic glycopeptides (MAG) and glyconanoparticles.

Main Results:

Recent efforts focus on constructing effective glycoconjugate vaccines.
The association of B-cell and T-cell epitopes in glycoconjugates is key for immunogenicity.
Various synthetic strategies have been employed for diverse tumor-associated carbohydrate antigens.

Conclusions:

Glycoconjugates offer a viable strategy for cancer vaccine development.
Clustered glycoconjugates like MAG and glyconanoparticles show potential as anti-tumor therapeutics.
Continued research in glycoconjugate construction and immunological evaluation is crucial for advancing cancer immunotherapy.