Related Experiment Video
Updated: Jul 8, 2026

New Application of an Atmospheric Pressure Plasma Jet as a Neuro-protective Agent Against Glucose Deprivation-induced Injury of SH-SY5Y Cells
Published on: October 9, 2017
APP-based neuroprotective strategies
Dale E Bredesen1, Shahrooz Rabizadeh
1Buck Institute for Age Research and University of California, San Francisco, USA. dbredesen@buckinstitute.org
Abstract:
While much of the focus on Alzheimer's disease therapeutics has been directed at beta-amyloid peptide or at cholinergic synaptic transmission, recent data suggest that targeting signal transduction by the amyloid precursor protein (APP) itself may be an alternative approach with significant potential [1]. Here we discuss the possibility that APP-mediated signal transduction, downstream from amyloid-beta peptide production itself, may be an appropriate therapeutic target in Alzheimer's disease.
More Related Videos
Related Concept Videos
Neuroplasticity
Traumatic Brain Injury l: Introduction
Alzheimer's Disease: Treatment

