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Formulation and evaluation of flurbiprofen microemulsion

K W Ambade1, S L Jadhav, M N Gambhire

  • 1Department of Pharmaceutics, Bharati Vidyapeeth's College of Pharmacy, CBD Belapur, Sector-8, Navi-Mumbai, India.

Current Drug Delivery
|January 29, 2008
PubMed

Insights

This study developed microemulsions for topical Flurbiprofen (FP) delivery, bypassing gastrointestinal issues. Optimized formulations containing Isopropyl Myristate (IPM) showed superior anti-inflammatory effects and skin safety compared to gel cream.

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Dermatology

Background:

  • Gastrointestinal adverse effects limit oral Flurbiprofen (FP) use.
  • Topical drug delivery offers an alternative route to bypass systemic side effects.
  • Microemulsions present a potential vehicle for enhanced topical drug permeation.

Purpose of the Study:

  • To investigate microemulsion formulations for topical Flurbiprofen (FP) delivery.
  • To evaluate and optimize microemulsions for enhanced transdermal permeation and efficacy.
  • To assess the safety of microemulsion formulations for topical application.

Main Methods:

  • Development of pseudoternary phase diagrams for microemulsion formulation.
  • Preparation of microemulsions using Isopropyl Myristate (IPM) or Ethyl Oleate (EO) as oil phases, Aerosol OT, and Sorbitan Monooleate.
  • In vitro transdermal permeability studies using Keshary-Chien diffusion cells with excised rat skin.
  • Optimization using a 2(3) factorial design.
  • In vivo anti-inflammatory studies evaluating carrageenan-induced rat paw edema.
  • Histopathological examination of rat skin.

Main Results:

  • Flurbiprofen (FP) exhibited higher in vitro permeation from IPM-based microemulsions compared to EO-based ones.
  • Optimized IPM microemulsions demonstrated significantly greater in vivo anti-inflammatory efficacy than a conventional gel cream.
  • Histopathological analysis confirmed the safety of the microemulsion formulation for topical use.

Conclusions:

  • Microemulsions containing Isopropyl Myristate (IPM) are effective vehicles for topical Flurbiprofen (FP) delivery.
  • This approach successfully bypasses gastrointestinal adverse effects associated with oral FP.
  • Microemulsions offer a promising and safe alternative for topical anti-inflammatory treatment.

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