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Related Concept Videos

Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...

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Updated: Jul 8, 2026

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
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Published on: October 7, 2021

Diagnostic tools for diabetic sensorimotor polyneuropathy.

Keri A Kles1, Vera Bril

  • 1Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA.

Current Diabetes Reviews
|January 29, 2008
PubMed
Summary

Diabetic sensorimotor polyneuropathy (DSP) often develops despite risk factor control. Accurate diagnosis using various tools is crucial for early detection and preventing severe diabetic complications.

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Published on: January 3, 2011

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Last Updated: Jul 8, 2026

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Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies
11:29

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Published on: January 3, 2011

Area of Science:

  • Neurology
  • Endocrinology
  • Diabetology

Background:

  • Diabetes mellitus is a leading cause of mortality and morbidity in the US.
  • Diabetic microvascular complications (DMC), including diabetic sensorimotor polyneuropathy (DSP), pose significant health challenges.
  • Despite management of risk factors like blood glucose, cholesterol, and blood pressure, many diabetic patients develop DSP.

Purpose of the Study:

  • To review the diagnostic tools essential for the accurate evaluation of diabetic sensorimotor polyneuropathy (DSP).
  • To highlight the importance of early DSP detection in preventing long-term diabetic complications.

Main Methods:

  • Review of current diagnostic methodologies for DSP.
  • Description of symptom scoring systems.
  • Explanation of quantitative sensory testing (QST).
  • Overview of electrophysiological assessment techniques.

Main Results:

  • Multiple diagnostic tools are available for DSP identification.
  • Accurate diagnosis is key to effective management strategies.
  • Early detection facilitates preventative care, reducing risks of ulcers and amputations.

Conclusions:

  • A composite approach utilizing symptom scores, QST, and electrophysiology is necessary for comprehensive DSP diagnosis.
  • Timely and accurate diagnosis of DSP is critical for mitigating severe outcomes in diabetic patients.