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Related Experiment Video

Updated: Jul 8, 2026

Analysis of Apoptosis in Zebrafish Embryos by Whole-mount Immunofluorescence to Detect Activated Caspase 3

Analysis of Apoptosis in Zebrafish Embryos by Whole-mount Immunofluorescence to Detect Activated Caspase 3

Published on: December 20, 2013

Fish and apoptosis: molecules and pathways.

N M S dos Santos¹, A do Vale, M I R Reis

¹Instituto de Biologia Molecular e Celular, Rua do Campo Alegre 823, 4150-180 Porto, Portugal. nsantos@ibmc.up.pt

Current Pharmaceutical Design

|January 29, 2008

Summary

This summary is machine-generated.

Fish possess conserved apoptosis pathways similar to mammals, making them valuable models for studying cell death and related human diseases. This research highlights their utility in advancing pharmaceutical design and aquaculture health.

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Last Updated: Jul 8, 2026

Analysis of Apoptosis in Zebrafish Embryos by Whole-mount Immunofluorescence to Detect Activated Caspase 3

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Published on: December 20, 2013

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Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

Published on: February 16, 2015

Area of Science:

Cell Biology
Developmental Biology
Comparative Medicine

Background:

Apoptosis, or programmed cell death, is a fundamental biological process conserved across species.
While conserved in invertebrates and mammals, fish offer a unique vertebrate model bridging developmental and physiological gaps.

Purpose of the Study:

To review structural and functional data on key apoptosis regulators in fish.
To establish fish as advantageous models for studying vertebrate apoptosis and related human disorders.

Main Methods:

Review of existing literature on apoptosis-related molecules (death-receptor, Bcl-2, caspase families) and mechanisms in fish.
Comparative analysis of fish apoptosis pathways with those in mammals, invertebrates, and humans.

Main Results:

Fish exhibit apoptotic pathways functionally and molecularly equivalent to mammals.
Key apoptosis-related gene families and mechanisms are conserved in fish.

Conclusions:

Fish are highly suitable animal models for investigating apoptosis.
Findings have significant implications for understanding human apoptosis-related diseases and pharmaceutical development.
Utilizing fish models can benefit aquaculture through improved health and disease management strategies.