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Related Concept Videos

Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Production of Formed Elements01:34

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:

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Related Experiment Video

Updated: Jul 8, 2026

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
14:37

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

Stem cell model of hematopoiesis.

Alice M S Cheung1, Yok-Lam Kwong, Raymond Liang

  • 1Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong.

Current Stem Cell Research & Therapy
|January 29, 2008
PubMed
Summary

Hematopoietic stem cells (HSCs) possess self-renewal and differentiation capabilities. Research explores their regulation and the role of novel genes, offering insights into leukemic stem cells (LSCs).

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Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition
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Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition

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A Culture Method to Maintain Quiescent Human Hematopoietic Stem Cells
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A Culture Method to Maintain Quiescent Human Hematopoietic Stem Cells

Published on: May 17, 2021

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Last Updated: Jul 8, 2026

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
14:37

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition
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Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition

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A Culture Method to Maintain Quiescent Human Hematopoietic Stem Cells
07:14

A Culture Method to Maintain Quiescent Human Hematopoietic Stem Cells

Published on: May 17, 2021

Area of Science:

  • Hematology
  • Stem Cell Biology
  • Molecular Biology

Background:

  • Hematopoietic stem cells (HSCs) are crucial for blood formation, exhibiting self-renewal and multi-lineage differentiation.
  • Characterization and purification of HSCs involve surface phenotypes, metabolic markers, and functional assays in murine and human studies.
  • HSC cell-fate is intrinsically regulated by transcription factors (e.g., Hox, SCL) and extrinsically by developmental signaling pathways (e.g., Notch, Wnt, BMP).

Purpose of the Study:

  • To review the intrinsic and extrinsic regulatory mechanisms governing hematopoietic stem cell function.
  • To highlight recent advances in understanding HSC regulation through genome research and gene profiling.
  • To connect HSC biology with the concept of leukemic stem cells (LSCs).

Main Methods:

  • Review of murine and human studies on HSC characterization and purification.
  • Analysis of intrinsic regulatory factors including transcription factors and telomerase.
  • Examination of extrinsic regulatory pathways such as Notch, Wnt, and BMP signaling.

Main Results:

  • HSC function is governed by a complex interplay of intrinsic genetic factors and extrinsic signaling pathways.
  • Novel genes with previously unknown roles in hematopoiesis are being identified through advanced genomic research.
  • The stem cell model provides a framework for understanding leukemic stem cells (LSCs) with similar self-renewing properties.

Conclusions:

  • Hematopoiesis is a tightly regulated process involving multiple genetic and signaling pathways.
  • Ongoing research continues to uncover novel regulators of HSC function.
  • Understanding HSC biology is critical for elucidating the mechanisms of leukemic stem cells and developing targeted therapies.