Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stem cells and blastema cells.

Panagiotis A Tsonis1

  • 1Department of Biology and Center for Tissue Regeneration and Engineering, University of Dayton, Dayton, OH 45469-2320, USA. panagiotis.tsonis@notes.udayton.edu

Current Stem Cell Research & Therapy
|January 29, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

miR-26 Deficiency Causes Alterations in Lens Transcriptome and Results in Adult-Onset Cataract.

Investigative ophthalmology & visual science·2024
Same author

miR-26 deficiency causes alterations in lens transcriptome and results in adult-onset cataract.

bioRxiv : the preprint server for biology·2024
Same author

Effects of vitamin D metabolites on axolotl limb regeneration.

Development, growth & differentiation·2023
Same author

Abnormal Limb Regeneration without Tumor Production in Adult Newts Directed by Carcinogens, 20-Methylcholanthrene and Benzo (α) pyrene: (amphibia/limb regeneration/carcinogen/teratogenesis).

Development, growth & differentiation·2023
Same author

Effects of a Carcinogen, N-methyl-N'-nitro-N-nitrosoguanidine on Blastema Cells and Blastema Formation in Newt Limb Regeneration: (blastema cells/carcinogen/cell surface properties/basement lamella/abnormal regeneration).

Development, growth & differentiation·2023
Same author

Newt regeneration genes regulate Wingless signaling to restore patterning in <i>Drosophila</i> eye.

iScience·2021
Same journal

Transplanted Cerebrospinal Fluid-Contacting Neurons Alleviate Spasticity Following Spinal Cord Injury in Mice.

Current stem cell research & therapy·2026
Same journal

Ear Cartilage Reconstruction: From Regenerative Medicine to Reconstructive Surgery.

Current stem cell research & therapy·2026
Same journal

Application of Wharton's Jelly Derived from Human Umbilical Cord in Tissue Engineering.

Current stem cell research & therapy·2026
Same journal

Gestational Age, Maternal Age, and Culture Dynamics Shape the Pluripotency Marker Profile of Primary Amniocytes: Insights for Stem Cell Biology and Regenerative Applications.

Current stem cell research & therapy·2026
Same journal

Outcomes of Chimeric Antigen Receptor T-cell (CAR-T) Cell Therapy in Hematological Malignancies - A Systematic Review and Meta Analysis.

Current stem cell research & therapy·2026
Same journal

Preface.

Current stem cell research & therapy·2026
See all related articles

Salamanders routinely regenerate body parts by dedifferentiating cells, unlike mammals. This process may share molecular mechanisms with embryonic stem cell maintenance and adult cell reprogramming.

Area of Science:

  • Regenerative Medicine
  • Developmental Biology
  • Comparative Biology

Background:

  • Mammalian regenerative capacity is limited compared to salamanders.
  • Salamanders can regenerate complex body parts, including limbs and organs.
  • Regeneration involves dedifferentiation of mature cells, not stem cell recruitment.

Purpose of the Study:

  • To explore the mechanisms of salamander regeneration.
  • To compare salamander regeneration with mammalian stem cell biology.
  • To identify shared molecular pathways between regeneration and stem cell maintenance.

Main Methods:

  • Review of existing literature on salamander regeneration.
  • Comparison of cellular reprogramming in salamanders and mammals.

Related Experiment Videos

  • Analysis of molecular signatures in dedifferentiated and stem cells.

    • Main Results:

    • Salamander regeneration involves transdifferentiation of terminally differentiated cells.
    • This process may involve mechanisms similar to embryonic stem cell maintenance.
    • Potential shared molecular pathways exist between salamander regeneration and mammalian stem cell reprogramming.

    Conclusions:

    • Salamander regeneration offers insights into vertebrate regenerative potential.
    • Understanding these mechanisms could advance stem cell therapies.
    • Bridging regeneration and stem cell biology may reveal novel therapeutic targets.