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Calmodulin-dependent Signaling01:16

Calmodulin-dependent Signaling

Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
Protein Kinases and Phosphatases02:54

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Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
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Phosphorylation01:02

Phosphorylation

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Updated: Jul 8, 2026

Pull-down of Calmodulin-binding Proteins
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Pull-down of Calmodulin-binding Proteins

Published on: January 23, 2012

Effect of Ca2+ on beta-propeller phytases.

Shijun Fu1, Jianyi Sun, Lichun Qian

  • 1Animal Science College, Zhejiang University, The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Hangzhou, 310029, PR China. fsj729@yahoo.com.cn

Protein and Peptide Letters
|January 29, 2008
PubMed
Summary

Beta-propeller phytases (BPPs) from Bacillus are crucial enzymes. This review details how calcium (Ca2+) impacts BPPs activity, stability, and structure, optimizing their use in various applications.

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The Importance of Correct Protein Concentration for Kinetics and Affinity Determination in Structure-function Analysis
19:16

The Importance of Correct Protein Concentration for Kinetics and Affinity Determination in Structure-function Analysis

Published on: March 17, 2010

Area of Science:

  • Biochemistry
  • Enzymology
  • Molecular Biology

Background:

  • Beta-propeller phytases (BPPs) are a distinct enzyme class.
  • Primarily sourced from Bacillus species.
  • Widely applied in animal nutrition, human health, and environmental protection.

Purpose of the Study:

  • To review the significant effects of calcium (Ca2+) on BPPs.
  • To elucidate the Ca2+ influence on catalytic activity, thermal stability, and structural conformation.

Main Methods:

  • Literature review of studies on Beta-propeller phytases.
  • Analysis of existing data on Ca2+ interactions with BPPs.
  • Focus on catalytic, stability, and structural properties.

Main Results:

  • Ca2+ is essential for the catalytic activity of BPPs.
  • Calcium ions influence the thermal stability of these enzymes.
  • Ca2+ binding affects the structural conformation of BPPs.

Conclusions:

  • Calcium (Ca2+) plays a critical role in the function and stability of Beta-propeller phytases.
  • Understanding Ca2+ effects can optimize BPPs for industrial and therapeutic applications.
  • Further research into Ca2+-BPP interactions is warranted.